Publications by authors named "M D Ledesma"
Article Synopsis
- The immune system in chronic myeloid leukemia (CML) patients is significantly weakened, affecting their ability to respond to tumors, but shows improvement following effective treatment with tyrosine kinase inhibitors like imatinib.
- A study analyzed gene expression of various immune mediators in 171 blood samples from CML patients over their first year on imatinib, comparing it with samples from healthy donors.
- Results indicated that most immune mediators initially declined but largely normalized over time, while also revealing different patterns in optimal versus non-optimal treatment responders.
Article Synopsis
- - Niemann-Pick disease Type C (NPC) is linked to mutations in the NPC1 protein that disrupt cholesterol transport, leading to lipid buildup and psychiatric problems.
- - In an NPC mouse model, researchers discovered that mGluR (metabotropic glutamate receptors) accumulate abnormally inside cells, affecting their function and leading to changes in long-term depression (a form of synaptic plasticity).
- - Treatment with the mGluR antagonist CTEP lowered mGluR-related issues and improved psychiatric symptoms, suggesting alterations in mGluR play a role in NPC and offering potential new therapies for affected individuals.
Behavioural analysis has been attracting significant attention as a broad indicator of sub-lethal toxicity and has secured a place as an important subdiscipline in ecotoxicology. Among the most notable characteristics of behavioural research, compared to other established approaches in sub-lethal ecotoxicology (e.g.
View Article and Find Full Text PDFNDM-5-producing Klebsiella pneumoniae ST258 in a university hospital in Argentina.
J Antimicrob Chemother
December 2024
Background: A drastic increase in carbapenem resistance among Klebsiella pneumoniae isolates occurred during the period 2019-22. Three epidemiological changes could be evidenced: (i) NDM became the predominant carbapenemase; (ii) NDM-5 replaced NDM-1; and (iii) the emergence of NDM-producing K. pneumoniae ST258 (NDM-KpST258).
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