Publications by authors named "M D Lebedeva"
Schizophrenia, a severe psychiatric, neurodevelopmental disorder affecting about 0.29-1 % of the global population, is characterized by hallucinations, delusions, cognitive impairments, disorganized thoughts and speech, leading to significant social withdrawal and emotional blunting. During the 1980s, considerations about diseases that result from complex interactions of genetic background and environmental factors started to appear.
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- The study measured the electrical impedance and pulsation ranges of brachial and femoral arteries in rats after 14 days of hindlimb unloading (a model for microgravity).
- Results showed that the femoral artery constricted while the brachial artery dilated, with both exhibiting reduced pulsation dynamics.
- The ability of the femoral artery to switch to an active pulsatile mode during bloodletting was significantly lower in unloaded rats than in control rats, indicating potential negative effects of microgravity on blood circulation.
Background: α-Klotho deficiency may increase cardiovascular risks and worsen survival. We evaluated the association of α-Klotho with cardiovascular and all-cause mortality in pre-dialysis chronic kidney disease (CKD) patients.
Methods: In this prospective study, 75 non-diabetic CKD stage 3b-4 patients were followed-up for a median of 8 years.
Aim: To determine biomarkers of anemia of chronic disease (ACD) in patients with glomerulonephritis (GN) in the early stages of CKD, to assess their role as risk factors for cardiovascular complications (CVС).
Materials And Methods: Seventy nine patients with GN were studied, among them: 40 with primary сhronic GN (CGN), 39 with secondary forms:19 - GN with ANCA-associated systemic vasculitis, 20 - GN with systemic lupus erythematosus (SLE) at early (all I-II) CKD stages. In all patients, the level of serum C-reactive protein (CRP), hepcidin, interferon γ, and the circulating form of protein Klotho (s-Klotho) were determined.
Article Synopsis
- Adar2 mice are commonly used to study the effects of reduced RNA editing, specifically relating to the Gria2 subunit of the AMPA receptor, which impacts their circadian rhythms.
- The study found that Gria2 mice lost circadian rhythmicity in the hippocampus when compared to Adar2 mice, indicating a significant effect on their internal clock.
- These findings suggest that the postnatal increase in editing of the Gria2 subunit is important for the circadian clock's development in certain brain areas, raising questions about using Gria2 mice as controls in related experiments.