Publications by authors named "M D Kwiatkowski"

This paper presents the numerical analysis of the influence of air flow rate on the porous structure development of activated carbons prepared from macadamia nut shells. The analyses based on nitrogen and carbon dioxide isotherms were carried out by the new numerical clustering-based adsorption analysis method. Therefore, it was possible to evaluate the porous structure with high precision and reliability.

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Article Synopsis
  • The study investigated the impact of statin use on prostate cancer (PCa) development and prostate-specific antigen (PSA) levels in a cohort of 4,314 men over nearly 10 years.
  • Statin users (761 men) had significantly lower baseline and follow-up PSA levels compared to non-users, but the overall incidence of PCa was similar between the two groups, indicating statins did not reduce the risk of developing PCa.
  • Additionally, statin users had a higher risk of overall mortality, suggesting that while they had lower PSA levels, statin use did not confer a protective effect against prostate cancer.
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The present structure-activity relationship study investigates the development of novel chemosensitizers targeting therapy-resistant cancer stem cells (CSCs). We used 4'-((2-propyl-1-benzo[]imidazole-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid, derived from the angiotensin II type 1 receptor blocker telmisartan, as a lead structure, demonstrating that the biphenyl moiety is essential for chemosensitizing activity. Introducing a methyl carboxylate or carboxamide instead of the COOH-group significantly enhanced this effect, leading to the development of highly potent compounds.

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Contemporary scientific discussions are increasingly focusing on due to its complex influence on intestinal physiology. This article provides a comprehensive analysis of the various effects has on intestinal inflammation, while also exploring its potential associations with obesity and cardiovascular diseases. A systematic literature search was conducted using PubMed, Google Scholar, and ResearchGate with the following keywords: , obesity, cardiovascular risk, and inflammatory bowel diseases.

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