Publications by authors named "M D Kruizinga"
Background: Clinical trials for rare disorders have unique challenges due to low prevalence, patient phenotype variability and high expectations. These challenges are highlighted by our study on clonazepam in patients, a common cause of intellectual disability. Previous studies on Arid1b-haploinsufficient mice showed positive effects of clonazepam on various cognitive aspects.
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- The study aimed to validate an anti-TNFα clearance model to inform the timing of live vaccinations in infants who were exposed to these drugs during pregnancy.
- By analyzing data from newborns and using Bayesian optimization, the model accurately predicted drug concentrations in the PETIT cohort.
- Results showed that the model had high predictive accuracy, with 94% of adalimumab and 93% of infliximab levels falling within the expected range, thus providing reliable guidance for clinicians on vaccination timing.
Background And Objective: In neonates, β-Lactam antibiotics are almost exclusively administered by intermittent infusion. However, continuous or prolonged infusion may be more beneficial because of the time-dependent antibacterial activity. In this pharmacokinetic/pharmacodynamic simulation study, we aimed to compare treatment with continuous, extended and intermittent infusion of β-lactam antibiotics for neonates with infectious diseases.
View Article and Find Full Text PDFBackground: The imposition of lockdowns during the severe acute respiratory syndrome coronavirus-2 pandemic led to a significant decrease in pediatric care utilization in 2020. After restrictions were loosened, a surge in pediatric respiratory disease was observed in pediatric wards. The aim of this study was to quantify the effect of the lockdown(s) on the incidence of pediatric respiratory disease.
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- The study aimed to evaluate the impact of the COVID-19 pandemic on the psychological well-being of children and adolescents by analyzing hospital admission data for various psychological diagnoses during and before the pandemic.
- It found that overall pediatric admissions dropped by 28%, but there was a notable increase in psychosocial admissions, particularly for eating disorders (up 64%) and intentional intoxications (up 24%).
- The findings suggest a significant rise in pediatric psychiatric issues, highlighting the pandemic's adverse effects on mental health in young populations.