The primary drivers of private-sphere pro-environmental behaviour in five European countries during the Covid-19 pandemic.

Nowadays, when fighting climate change and other global environmental issues is of utmost urgency, the understanding of what drives pro-environmental behaviour has become a hot topic in both academic and practical circles. Some earlier studies unravelled the complexity of the underlying factors of pro-environmental conduct, yet more studies are needed to understand the socio-cultural premises of such behaviour in different countries. The main aim of this paper is to offer a comprehensive analysis of the importance of pro-environmental behaviour drivers across five countries in Europe, namely Greece, Poland, Portugal, Sweden, and the United Kingdom.

BCL11B, FLT3, NOTCH1 and FBXW7 mutation status in T-cell acute lymphoblastic leukemia patients.

T-cell acute lymphoblastic leukemia is a heterogeneous malignancy originating from developing lymphocyte precursors likely due to mutations in genes regulating thymocyte differentiation. Here, we characterized mutation status of BCL11B and FLT3 genes, presumably involved in T-ALL, together with FBXW7 and NOTCH1 as known players in T-ALL in 65 pediatric T-cell acute lymphoblastic leukemia patients. We also aimed at the assessment of prognostic value of NOTCH1 and FBXW7 mutations in ALL-IC BFM 2002 protocol.

T-cell acute lymphoblastic leukaemia: recent molecular biology findings.

For many years, T-cell acute lymphoblastic leukaemia (T-ALL) has been considered and treated as a single malignancy, but divergent outcomes in T-ALL patients receiving uniform treatment protocols encouraged intensive research on the molecular biology of this disease. Recent findings in the field demonstrate that T-ALL is much more heterogeneous than originally believed and extremely diverse outcomes of patients require refinement of T-ALL classification, leading to subtype-specific adjustment of treatment. Many different biological features of T-ALL blast cells have recently been found to contribute to disease development and patient outcome and their analysis could potentially be introduced into improved diagnostics and classification of the disease.