Publications by authors named "M D Huguet"
Article Synopsis
- The study aimed to evaluate whether extended infusions (EI) of β-lactam antibiotics are more effective than intermittent infusions (II) in treating febrile neutropenia, a condition common in patients receiving chemotherapy and stem cell transplants.
- In a clinical trial involving 150 patients from four Spanish hospitals, those receiving EI experienced a slightly lower success rate at day 5 compared to those on II (50.6% vs. 63.0%), although not statistically significant.
- The research concluded that routine use of EI for β-lactams in this patient group is not supported, suggesting the need for further studies to address the diverse clinical aspects of febrile neutropenia.
Article Synopsis
- Haploidentical hematopoietic stem cell transplantation (haploSCT) is gaining traction as a viable option for patients without suitable donors, especially following the advent of post-transplantation cyclophosphamide (PTCy).
- This study analyzed 372 adult haploSCT patients who received different GVHD prophylaxis strategies, finding no significant differences in acute GVHD rates among the groups, but noted lower chronic GVHD rates in patients treated with single-agent tacrolimus.
- The results indicate that while all three prophylaxis methods (single-agent tacrolimus, CNI + MMF, sirolimus + MMF) produced similar short-term outcomes, further research is needed to explore differences in chronic GVHD
Background: Ascending aorta dilation and aortic valve degeneration are common complications in patients with bicuspid aortic valve. Several retrospective studies have suggested the benefit of statins in reducing these complications. This study aimed to determine whether atorvastatin treatment is effective in reducing the growth of aortic diameters in bicuspid aortic valve and if it slows the progression of valve calcification.
View Article and Find Full Text PDFAims: Pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) using very high-power short-duration (vHPSD) radiofrequency (RF) ablation proved to be safe and effective. However, vHPSD applications result in shallower lesions that might not be always transmural. Multidetector computed tomography-derived left atrial wall thickness (LAWT) maps could enable a thickness-guided switching from vHPSD to the standard-power ablation mode.
View Article and Find Full Text PDFBackground: Transitions from sexual to asexual reproduction are common in eukaryotes, but the underlying mechanisms remain poorly known. The pea aphid-Acyrthosiphon pisum-exhibits reproductive polymorphism, with cyclical parthenogenetic and obligate parthenogenetic lineages, offering an opportunity to decipher the genetic basis of sex loss. Previous work on this species identified a single 840 kb region controlling reproductive polymorphism and carrying 32 genes.
View Article and Find Full Text PDF