Publications by authors named "M D Hourihan"
In the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse and subsequent harm), resulted in 2 deaths. The causative strain, B. pseudomallei ATS2021, was unintentionally imported into the United States in an aromatherapy spray manufactured in India.
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- Schizophrenia's complexity has made it difficult to understand its mechanisms and develop effective treatments; a new study addresses this by examining transcriptomic changes at the single-cell level in the human prefrontal cortex of 140 individuals.
- The researchers found that excitatory neurons were the most affected, with changes related to neurodevelopment and synapse function, and identified both common and rare genetic risk factors influencing these neuronal alterations.
- Their findings reveal two distinct groups of individuals with schizophrenia based on specific excitatory and inhibitory neuron states, linking genetic risk to cellular changes and enhancing our understanding of schizophrenia's underlying biology.
Inhaled Epoprostenol to Facilitate Safe Transport in Legionnaires' Disease.
Prehosp Disaster Med
February 2020
Hypoxemic patients often desaturate further with movement and transport. While inhaled epoprostenol does not improve mortality, improving oxygenation allows for transport of severely hypoxemic patients to tertiary care centers with a related improvement in mortality rates. Extracorporeal membrane oxygenation (ECMO) use is increasing in frequency for patients with refractory hypoxemia, and with increasing regionalization of care, safe transport of hypoxemic patients only becomes more important.
View Article and Find Full Text PDFIn May 2018, an outbreak of gastrointestinal illnesses due to norovirus occurred at Camp Arifjan, Kuwait. The outbreak lasted 14 days, and a total of 91 cases, of which 8 were laboratory confirmed and 83 were suspected, were identified. Because the cases occurred among a population of several thousand service members transiting through a crowded, congregate setting of open bays of up to 250 beds, shared bathrooms and showers, and large dining facilities, the risk of hundreds or thousands of cases was significant.
View Article and Find Full Text PDFPurpose: Lacrimal gland lesions have diverse pathologies. Bone remodelling on imaging may suggest a benign lacrimal gland pleomorphic adenoma (LGPA) rather than a malignant process.
Methods: The authors report a case of malignant pleomorphic adenocarcinoma, which was misdiagnosed clinico-radiologically as a benign LGPA.