Statistical principles in neurointervention part 2. Multivariable analysis: generalized linear models, modification, confounding, and mediation.

This two part series on statistical principles in neurointervention offers a comprehensive foundation for neurointerventionalists to engage with both fundamental and advanced statistical principles. This series aims to equip neurointerventionalists with essential statistical knowledge for critically reviewing literature and conducting methodologically sound research. Part one of this series covered fundamental concepts such as frequentism, study types, data types, summarization, visualization, hypothesis testing, and univariable analysis.

Statistical principles in neurointervention part 1: basic principles, descriptive statistics and univariable analysis.

Neurointervention has seen significant advancements in recent decades with the adoption of myriad new technologies and techniques. Initially reliant on case reports and small case series, we now benefit from multicenter studies and randomized trials that can provide robust practice-changing evidencea and often employ sophisticated statistical methods. This two-part series on statistical principles in neurointervention aims to equip neurointerventionalists with essential statistical knowledge for critically reviewing literature and conducting methodologically sound research.

Deceased Donor Infectious Diseases Testing and Antimicrobial Use: Surveys of Organ Procurement Organizations and Transplant Professionals.

Background: Donor screening and antimicrobial management processes are inconsistent across organ procurement organizations (OPOs) and transplant centers. As part of a Controversies Conference addressing the evaluation and management of infectious diseases (ID) in deceased donors sponsored by the American Society of Transplantation (AST), two online pre-meeting surveys were developed to inform conference proceedings and assess current practices and opinions on donor screening and antimicrobial management.

Methods: Survey 1 addressed the current state of deceased donor ID testing, culture data communication, antimicrobial utilization, and involvement of transplant ID during donor management and was distributed to all 56 United States OPOs.

Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study.

Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City.

Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home.

Abandonment of prescriptions in medically underserved areas: Primary medication non-adherence in community pharmacies in the delta region of the United States.

Background: In the U.S. alone, medication non-adherence is estimated to cause 1 in 10 hospitalizations, approximately 125,000 deaths annually, and cost the U.