Publications by authors named "M D Groves"
The enzyme 1-deoxy-d-xylulose-5-phosphate synthase (DXPS) catalyses the first step of the MEP pathway, a key process for isoprenoid biosynthesis in bacteria that is absent in humans, making it a promising drug target. We present the structure of Mycobacterium tuberculosis DXPS in its apo form, obtained through a soaking method that removes thiamine diphosphate (ThDP) and metals from pre-formed crystals. The apo structure had three regions with absence of electron density near the active site that are unique to the apo form of the enzyme.
View Article and Find Full Text PDFSulfated zirconium oxide (SZO) catalyzes the hydrogenolysis of isotactic polypropylene (iPP, M=13.3 kDa, Đ=2.4,
Unlabelled: Patients who have radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an obviously invasive and dangerous procedure. Here we present a new workflow termed "CSF-BAM" that simultaneously identifies cell or T cell receptor rearrangements, neuploidy, and using PCR-mediated amplification of both strands of the DNA from CSF samples.
View Article and Find Full Text PDFArticle Synopsis
- The study reviewed six pediatric osteosarcoma patients with brain metastases at Johns Hopkins Hospital, revealing a grim median survival of just 2.5 months post-diagnosis.
- Despite various treatments like chemotherapy, surgery, and radiation, most outcomes were fatal, although one patient showed a remarkable 13-month survival with a combination treatment, suggesting the potential of multimodal therapies.
- The findings stress the importance of careful monitoring for neurological symptoms and highlight the need for further research into new treatment strategies and the biology of metastasis to improve patient outcomes.
Background And Objectives: The optimal management strategy for pediatric patients with symptomatic moyamoya disease (MMD) is not well established. This systematic review and meta-analysis compares surgical vs conservative management and direct/combined bypass (DB/CB) vs indirect bypass (IB) for pediatric patients with symptomatic MMD.
Methods: MEDLINE and PubMed were searched from inception to March 17, 2024.