Publications by authors named "M D Gonzalez de Llano"
Article Synopsis
- * Findings suggest that PARP-1's DNA-binding activity is crucial for its anti-HIV-1 effects, while its catalytic activity is not necessary for this function.
- * The research indicates that PARP-1 influences the production phase of the viral life cycle and enhances the levels of virion-associated envelope protein (Env), leading to increased infectivity of the virus.
Schlafen (SLFN) is a family of proteins upregulated by type I interferons with a regulatory role in translation. Intriguingly, SLFN14 associates with the ribosome and can degrade rRNA, tRNA, and mRNA in vitro, but a role in translation is still unknown. Ribosomes are important regulatory hubs during translation elongation of mRNAs rich in rare codons.
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- Primary Sjögren's syndrome (pSS) is an autoimmune disorder influenced by type I and II interferons, with an inadequate focus on the role of innate immune cells like NK and dendritic cells.
- Researchers found a specific NK cell subset in pSS patients that is more effective at killing cells and detected higher levels of a certain type of dendritic cell (cDC2) involved in inflammation.
- The study suggests that the interaction between these NK cells and cDC2s, along with specific signaling pathways, plays a key role in pSS development, highlighting potential new targets for therapy.
Results of phase 2 randomized multi-center study to evaluate the safety and efficacy of infusion of memory T cells as adoptive therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and/or lymphopenia (RELEASE NCT04578210).
Cytotherapy
January 2024
Background Aims: There are currently no effective anti-viral treatments for coronavirus disease 2019 (COVID-19)-hospitalized patients with hypoxemia. Lymphopenia is a biomarker of disease severity usually present in patients who are hospitalized. Approaches to increasing lymphocytes exerting an anti-viral effect must be considered to treat these patients.
View Article and Find Full Text PDFPurpose: Recently developed handheld ultrasound devices (HHUD) represent a promising method to evaluate the cardiovascular abnormalities at the point of care. However, this technology has not been rigorously evaluated. The aim of this study was to explore the correlation and the agreement between the LVEF (Left Ventricular Ejection Fraction) visually assessed by a moderately experienced sonographer using an HHUD compared to the routine LVEF assessment performed at the Echocardiography Laboratory.
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