miR-24-3p Is Antiviral Against SARS-CoV-2 by Downregulating Critical Host Entry Factors.

Despite all the progress in treating SARS-CoV-2, escape mutants to current therapies remain a constant concern. Promising alternative treatments for current and future coronaviruses are those that limit escape mutants by inhibiting multiple pathogenic targets, analogous to the current strategies for treating HCV and HIV. With increasing popularity and ease of manufacturing of RNA technologies for vaccines and drugs, therapeutic microRNAs represent a promising option.

Flow-Dependent Modulation of Endothelial Ca Dynamics by Small Conductance Ca-Activated K Channels in Mouse Carotid Arteries.

Background: Small conductance Ca activated K channels (K2.3) are important regulators of vascular function. They provide Ca-dependent hyperpolarization of the endothelial membrane potential, promoting agonist-induced vasodilation.

Isolation of mixed valence charge-neutral Ag, and dicationic Ag nano-clusters stabilized by carbene-phosphaalkenides.

Cyclic alkyl(amino) carbene (cAAC)-supported phosphaalkenides (cAACP) have been employed as ligands for the isolation of two atomically precise mixed valence paramagnetic AgI/012Cl, and AgI/010, nano-clusters [(Me-cAACP)AgCl] (2), and [(Me-cAACP)Ag](NTf) (4). 2 and 4 have been structurally characterized by single-crystal X-ray diffraction revealing the presence of three Ag atoms, nine Ag ions (2); and two Ag atoms, eight Ag ions (4), respectively. The clustering inorganic unit AgCl in 2 has been found to be surrounded by six mono-anionic μ-cAACP moieties having 3-bar symmetry.