Publications by authors named "M D Fedorova"
Phospholipids containing oxidized esterified PUFA residues (OxPLs) are increasingly recognized for multiple biological activities and causative involvement in disease pathogenesis. Pharmacokinetics of these compounds in blood plasma is essentially not studied. Human plasma contains both genuine phospholipases A (PAF-AH (also called Lp-PLA) and sPLA) and multifunctional enzymes capable of removing sn-2 residues in native and oxidized PLs (LCAT, PRDX6).
View Article and Find Full Text PDFThe white poplar () is a dioecious woody plant with significant potential for the phytoremediation of soils. To realize this potential, it is necessary to utilize growth-promoting microorganisms. One potential source of such beneficial microorganisms is the rhizosphere community of wild-growing trees.
View Article and Find Full Text PDFHead and neck paragangliomas (HNPGLs) are rare neoplasms that, along with pheochromocytomas and extra-adrenal paragangliomas, are associated with inherited mutations in at least 12 susceptibility genes in approximately 40% of cases. However, due to the rarity of HNPGLs, only a series of small-scale studies and individual cases have reported mutations in additional genes that may be involved in tumorigenesis. Consequently, numerous disease-causing mutations and genes responsible for the pathogenesis of HNPGLs remain poorly investigated.
View Article and Find Full Text PDFObjective: To study the incidence of sudden cardiac death (SCD) among overall and primary morbidity of diseases of the circulatory system (DCS) during the COVID-19 pandemic, as well as several years before it in urban and rural populations of the Penza region.
Material And Methods: Statistical analysis of data using correlation (Pearson's coefficient), regression methods, t-test was performed to determine the significance of results.
Results: The higher incidence of DCS among men in urban areas has been found.
Article Synopsis
- Researchers discovered that Lactiplantibacillus plantarum 8p-a3, a probiotic strain, shows significant changes in its extracellular membrane vesicles when developing resistance to antibiotics (amoxicillin and clarithromycin).
- These changes are linked to large genome rearrangements and alterations in how the strain responds to various antimicrobials, as well as an increase in virulence factors.
- The study highlights how the structure and function of these vesicles may adapt to help the bacteria survive under the pressure of antibiotics, aiding in the understanding of probiotic safety and effectiveness.