Regularization by denoising: Bayesian model and Langevin-within-split Gibbs sampling.

This paper introduces a Bayesian framework for image inversion by deriving a probabilistic counterpart to the regularization-by-denoising (RED) paradigm. It additionally implements a Monte Carlo algorithm specifically tailored for sampling from the resulting posterior distribution, based on an asymptotically exact data augmentation (AXDA). The proposed algorithm is an approximate instance of split Gibbs sampling (SGS) which embeds one Langevin Monte Carlo step.

Flow characteristics of paste tailings in surface disposal: the role of pyrite content.

The flow characteristics of paste tailings (PT), including uncemented and lightly cemented paste tailings (UPT/LCPT), are critical for pipeline transport and surface paste disposal. These properties, particularly yield stress and viscosity, may be significantly affected by the presence of sulfide minerals like pyrite in tailings from hard rock mines. Pyrite's oxidative capacity alters the chemistry of mixtures, impacting their rheological behavior.

Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation.

In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal the presence of the marine dinoflagellate Vulcanodinium rugosum and its associated cyclic imine toxins. Specifically, we show that the toxin PortimineA, strongly enriched in environmental samples, impedes ribosome function in human keratinocytes, which subsequently activates the stress kinases ZAKα and P38 and promotes the nucleation of the human NLRP1 inflammasome, leading to the release of IL-1β/IL-18 pro-inflammatory cytokines and cell death.

Structural dynamics of camel milk proteins during digestion: Insights from 2D homo correlation and 2D hetero-correlation spectroscopy.

This study investigates camel milk protein structural dynamics during digestion using Fourier Transform Infrared (FTIR) spectroscopy and Two-Dimensional Infrared (2D-IR) homo-correlation and hetero-correlation analysis. The synchronous 2DIR homo-correlation map reveals that NH bending and C-N stretching vibrations (amide II) are sensitive to digestion, indicating significant impacts on secondary structures. The asynchronous 2DIR homo-correlation indicates a stepwise process, where initial disruptions in NH interactions precede changes in CO stretching vibrations (amide I), highlighting the sequence of structural alterations during protein unfolding and degradation.