Publications by authors named "M D Dunning"
Background: Existing research highlights an increase in psychedelic microdosing, particularly for therapeutic purposes and as a means for self-enhancement. However, we know little about the different routes into and out of microdosing, particularly by those who do not consume other illicit substances, and of the processes involved in the development, maintenance, and cessation of practices.
Methods: Drawing upon a trans-national interview-based study of 23 participants actively microdosing (n = 19), about to start (n = 3), or who were past users (n = 1), we develop a phased-based analysis of different user pathways.
Article Synopsis
- Physiological shear stress typically helps maintain vascular health by promoting protective molecules in endothelial cells, but this may not hold true in individuals with atherosclerosis.
- Researchers examined the differences in endothelial cell (EC) responses to shear stress between healthy and atherosclerotic arteries using advanced imaging and RNA sequencing techniques.
- Results indicated that endothelial cells in diseased arteries showed higher inflammatory markers and a significant reduction of the protective factor KLK10, suggesting a disruption in the protective effects of physiological shear stress in atherosclerotic conditions.
Article Synopsis
- The study develops a new method to identify genetic variants that increase breast cancer risk by focusing on variants in gene regulatory regions, using genome-wide association studies (GWAS) as a basis.
- Through analysis of microarray data from normal breast tissue, the researchers identified over 54,000 differential allelic expression QTLs (daeQTLs) linked to breast cancer risk, mapping these to relevant genes and loci.
- The findings highlight the connection between risk-related genetic variants and gene expression regulation, identifying candidate causal variants at the 5q14.1 locus that may influence breast cancer risk through alternative transcription mechanisms.
Background: Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription factor EPAS1 (HIF2A) has regulatory roles in endothelium, but its involvement in atherosclerosis remains unexplored.
View Article and Find Full Text PDFThe data on long-term antibiotic use following debridement, antibiotics, and implant retention (DAIR) for treatment of periprosthetic joint infections are limited. In this single-center retrospective study, we show that patients with eventual cessation of antibiotic suppression after DAIR had similar outcomes to those who remained on chronic antibiotic suppression.
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