Publications by authors named "M D Clark"
Background: We currently lack in the dementia field accurate, noninvasive, quick, and affordable screening tools for brain dysfunctions associated with early subtle risk of mild cognitive impairment (MCI). Our Kentucky aging cohort demonstrates that asymptomatic older individuals with MCI-like frontal memory-related brainwave patterns convert to MCI within a short 5-year period, as opposed to individuals with NC-like patterns (1) that remain normal 10 years later (2). Astrocyte reactivity influences amyloid-ß effects on tau pathology in preclinical Alzheimer's disease (3).
View Article and Find Full Text PDFObjective: The optimal method for cerebral protection during aortic arch reconstruction in neonates and infants is unknown. We compare the outcomes of deep hypothermic circulatory arrest and selective antegrade cerebral perfusion strategies in neonatal and infant cardiac surgery.
Methods: We retrospectively identified all patients aged less than 1 year who underwent aortic arch reconstruction from 2012 to 2023.
Article Synopsis
- Biological aging involves a gradual loss of homeostasis in molecular and cellular functions, particularly in the brain, which contains diverse cell types that differ in their aging resilience.
- This study offers an extensive single-cell RNA sequencing dataset of approximately 1.2 million transcriptomes from brain cells in young and aged mice, identifying 847 cell clusters and 14 age-biased clusters predominantly involving glial types.
- Key findings reveal specific gene expression changes with aging, including decreased neuronal function genes and increased immune-related genes, particularly in cells around the third ventricle of the hypothalamus, suggesting its critical role in the aging process of the mouse brain.
The marsupial moles are arguably Australia's most enigmatic marsupials. Almost indistinguishable from placental (eutherian) moles, they provide a striking example of convergent evolution. Exploring the genome of the southern marsupial mole, we provide insights into its unusual biology.
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