Self-Delivering RNAi Compounds for Reduction of Hyperpigmentation.

Purpose: Abnormal melanin synthesis causes hyperpigmentation disorders like melasma and lentigines, impacting psychological well-being. RNA interference (RNAi) uses small RNA molecules to inhibit gene expression by targeting specific mRNA, silencing genes involved in undesirable cellular functions. This study assessed INTASYL compounds, self-delivering RNAi molecules, designed to target and reduce tyrosinase gene expression to decrease pigmentation.

Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?

Purpose: Although germline genetic testing (GT) is recommended for all patients with ovarian cancer (OC) and some patients with endometrial cancer (EC), uptake remains low with multiple barriers. Our center performs GT in parallel with somatic testing via a targeted sequencing assay (MSK-IMPACT) and initiates testing in oncology clinics (mainstreaming). We sought to optimize our GT processes for OC/EC.

Advancing translational research in digital cardiac rehabilitation: The preparation phase of the Multiphase Optimization Strategy.

While digital cardiac rehabilitation (CR) is an effective alternative to center-based CR, its components and mechanisms of change remain poorly understood. The Multiphase Optimization Strategy (MOST) provides a framework that allows the effects of individual components of complex interventions to be studied. There is limited guidance within MOST on how to develop a conceptual model.

Climate change and polar marine invertebrates: life-history responses in a warmer, high CO2 world.

Polar marine invertebrates serve as bellwethers for species vulnerabilities in the face of changing climate at high latitudes of the Earth. Ocean acidification, warming/heatwaves, freshening, sea ice retreat and productivity change are challenges for polar species. Adaptations to life in cold water with intensely seasonal productivity has shaped species traits at both poles.