Publications by authors named "M D Bosque"
Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
Lancet Microbe
January 2024
Article Synopsis
- In June 2021, the WHO released a comprehensive catalogue of mutations in Mycobacterium tuberculosis that are linked to drug resistance, prompting researchers to evaluate its effectiveness for diagnosing drug-resistant tuberculosis in the relatively low prevalence area of Valencia, Spain.
- A retrospective genomic study analyzed 785 tuberculosis isolates collected between 2014-2016, utilizing whole-genome sequencing (WGS) to predict resistance profiles based on the catalogue and comparing these predictions with actual phenotypic results.
- The study found that while sensitivity for predicting resistance varied, with the highest at 85.4% for isoniazid, overall pan-susceptibility accuracy was 96.4%, highlighting some discrepancies in certain isolates that carried mutations known to cause borderline
An increase in spontaneous neurotransmission may be related to myofascial pain. Sympathetic neurons innervate most of the neuromuscular junction sand are involved in the modulation of synaptic transmission. Therefore, a direct action of stress on acetylcholine release is expected.
View Article and Find Full Text PDFIntroduction: An abnormal increase in spontaneous neurotransmission can induce subsynaptic knots in the myocyte called myofascial trigger points. The treatment of choice is to destroy these trigger points by inserting needles. However, 10% of the population has a phobia of needles, blood, or injuries.
View Article and Find Full Text PDFBackground: Radiotherapy (RT) is an essential element in cancer treatment: 50-70% of cancer patients receive RT at some time of the course of their disease. Of these, almost 95% experience some grade of radiation dermatitis (RD). RD can affect patient's quality of life during and after treatment.
View Article and Find Full Text PDFTransmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application.
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