Cascade screening for familial hypercholesterolemia from pediatric index cases diagnosed through universal screening.

Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant disorder causing elevated low density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. Universal cholesterol screening in childhood leads to children serving as the index case for their family, but efficacy of cascade screening and genetic counseling in this population is not well understood. The institutional pediatric lipid clinic database was queried from 2011 to 2022 for subjects <18 years who met clinical HeFH diagnostic criteria (N = 256).

Effect of annealing temperature on the structure and optical properties of ZnO thin films.

The effect of annealing temperature on the microstructure, defects and optical properties of ZnO thin films are investigated using sol-gel based spin coating method for a range of annealing temperatures from 200C to 500C. The correlation among the microstructure, defects, impurity content and the optical band gap of films of thickness about 10-12 nm is elucidated. The particle size increases and the optical band gap reduces with the annealing temperature.

Turner syndrome may be associated with hepatic adenoma.

Turner syndrome, caused by complete or partial loss of an X chromosome, is marked by a range of clinical manifestations including short stature, cardiovascular and renal disease. Hepatic involvement is an increasingly recognized concern. Steatosis and elevated transaminases are commonly observed in this population, but case reports have also described hepatic adenoma.

Familial Hypercholesterolemia Biomarker Distribution in Dried Blood Spots.

Objective: To evaluate distribution profiles of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apoB) as candidate markers of familial hypercholesterolemia in newborns, taking into consideration potential confounding factors, such as gestational age, birth weight, sex, and race.

Study Design: TC, LDL-C, and apoB were measured from 10 000 residual deidentified newborn dried blood spot cards. Concentrations for each biomarker were reported as multiples of the median, with emphasis on describing the 99th percentile values based on birth weight, gestational age, sex, and race.

Synthesis and characterization of SnO/rGO nanocomposite for an efficient photocatalytic degradation of pharmaceutical pollutant: Kinetics, mechanism and recyclability.

The SnO and SnO/rGO nanostructures were successfully synthesized using the facile hydrothermal synthesis technique. The prepared nanostructures were well studied using different techniques such as XRD, XPS, UV-DRS, FT-IR, EDX, SEM and HR-TEM analysis. The crystalline nature of SnO and SnO/rGO was confirmed by the XRD technique.