Two coding-complete genomes of porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) from field clinical samples in the Philippines.

We report two coding-complete genome sequences of porcine reproductive and respiratory syndrome virus 2 from field clinical samples obtained in 2021 (BA2021012A) and 2023 (ME20230008B-2) from the Philippines. BA2021012A (15,388 bp) is classified as a lineage L8C strain while ME20230008B-2 (15,513 bp) is a vaccine-like strain in lineage L7.

Expert Perspective: Management of Relapses in Giant Cell Arteritis.

Giant cell arteritis (GCA) is a relapsing large-vessel vasculitis with risk of serious ischemic manifestations including vision loss and vascular damage in the form of large-artery stenosis, aneurysms and dissections. Approximately 50% of patients treated with glucocorticoid (GC) monotherapy and 30% of patients receiving adjunctive therapy with tocilizumab experience disease relapses, often during the first 2 years after diagnosis. Although most relapses in GCA do not involve life- or organ-threatening presentations and can be controlled successfully, frequent relapses may lead to increased use of GC and consequent treatment-related morbidity, in addition to risk of further vascular damage.

High-density microneedle array-based wearable electrochemical biosensor for detection of insulin in interstitial fluid.

The development of point-of-care wearable devices capable of measuring insulin concentration has the potential to significantly improve diabetes management and life quality of diabetic patients. However, the lack of a suitable point-of-care device for personal use makes regular insulin level measurements challenging, in stark contrast to glucose monitoring. Herein, we report an electrochemical transdermal biosensor that utilizes a high-density polymeric microneedle array (MNA) to detect insulin in interstitial fluid (ISF).