Volatiles organic compounds in craft beers produced in Basilicata (Southern Italy).

The volatiles organic compounds of 21 samples of craft beers coming from Basilicata were detected, using a HS-SPME-GC-MS technique. The analysis showed the presence of various compounds (esters, alcohols, and terpenes), which were useful to determinate the aroma profiles of these beers. In addition, this profile was matched with the aroma profile of commercial beers, in order to establish the difference of the aroma profiles.

Fatty Acid Synthase as Interacting Anticancer Target of the Terpenoid Myrianthic Acid Disclosed by MS-Based Proteomics Approaches.

This research focuses on the target deconvolution of the natural compound myrianthic acid, a triterpenoid characterized by an ursane skeleton isolated from the roots of and from Nutt. (Onagraceae), using MS-based chemical proteomic techniques. Application of drug affinity responsive target stability (DARTS) and targeted-limited proteolysis coupled to mass spectrometry (t-LiP-MS) led to the identification of the enzyme fatty acid synthase (FAS) as an interesting macromolecular counterpart of myrianthic acid.

Investigational thymic stromal lymphopoietin inhibitors for the treatment of asthma: a systematic review.

Introduction: Severe asthma patients often remain uncontrolled despite high-intensity therapies. Biological therapies targeting thymic stromal lymphopoietin (TSLP), a key player in asthma pathogenesis, have emerged as potential options. Currently, the only TSLP inhibitor approved for the treatment of severe asthma is the immunoglobulin G (IgG) 2λ anti-TSLP monoclonal antibody (mAb) tezepelumab.

Artificial intelligence and pelvic fracture diagnosis on X-rays: a preliminary study on performance, workflow integration and radiologists' feedback assessment in a spoke emergency hospital.

Purpose: The aim of our study is to evaluate artificial intelligence (AI) support in pelvic fracture diagnosis on X-rays, focusing on performance, workflow integration and radiologists' feedback in a spoke emergency hospital.

Materials And Methods: Between August and November 2021, a total of 235 sites of fracture or suspected fracture were evaluated and enrolled in the prospective study. Radiologist's specificity, sensibility accuracy, positive and negative predictive values were compared to AI.

Enhanced Molecular Networking Shows sp. V1 as a Factory of Antioxidant Proline-Rich Peptides.

Two linear proline-rich peptides (-), bearing an N-terminal pyroglutamate, were isolated from the marine bacterium sp. V1, associated with the marine sponge , collected in the volcanic CO vents in Ischia Island (South Italy). Peptide production was triggered at low temperature following the one strain many compounds (OSMAC) method.