Publications by authors named "M D'Altilia"
Article Synopsis
- * The study included 259 patients with a mean age of 42.2 years, primarily suffering from ulcerative colitis or Crohn's disease, and investigated symptoms, close contact histories, and hospitalization related to COVID-19.
- * Findings revealed that only 12.3% experienced respiratory symptoms, with only 2 patients testing positive for SARS-CoV-2 antibodies, indicating that biologic treatment does not increase the risk of SARS-CoV-2 infection in these patients.
Background: Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental factors. Recently, it has been highlighted that three genetic markers, NOD2, MHC and MST1, were associated to distinct CD sites, supporting the concept that genetic variations may contribute to localize CD. Genetic markers, previously shown to be associated with inflammatory bowel disease (IBD), were tested in CD patients with the aim to better dissect the genetic relationship between ileal, ileocolonic and colonic CD and ascertain whether a different genetic background would support the three disease sites as independent entities.
View Article and Find Full Text PDFBackground: Few case reports describe the clinical features of pancreatic involvement in inflammatory bowel disease.
Aim: To investigate prevalence and disease course of inflammatory bowel disease children with pancreatitis and with exclusive hyperamylasemia and hyperlipasemia.
Methods: We used a web-registry to retrospectively identify paediatric inflammatory bowel disease patients with hyperamylasemia and hyperlipasemia.
Background: Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial, ear, and renal anomalies. The most common gene mutated in BOR patients is EYA1, the human homolog of the Drosophila eyes absent gene, while mutations in SIX1 gene, the human homolog of sine oculis, encoding a DNA binding protein interacting with EYA1, have been reported less frequently. Recently, mutations in another SIX family member, SIX5, have been described in BOR patients, however, this association has not been confirmed by other groups.
View Article and Find Full Text PDFBackground: The purpose was to assess in Italy the clinical features at diagnosis of inflammatory bowel disease (IBD) in children.
Methods: In 1996 an IBD register of disease onset was established on a national scale.
Results: Up to the end of 2003, 1576 cases of pediatric IBD were recorded: 810 (52%) ulcerative colitis (UC), 635 (40%) Crohn's disease (CD), and 131 (8%) indeterminate colitis (IC).