Improved three-filament thermal ionization mass spectrometry ion source for isotope ratio determination of two samples.

Rationale: In order to make a single-filament thermal ionization mass spectrometry (TIMS) instrument more versatile and efficient in element isotope analysis, a multifilament ion source has to be employed. In the currently used three-filament ion sources, the same sample must be loaded on all the evaporator filaments, because of the possibility of cross-contamination.

Methods: The elimination of cross-contamination in a TIMS three-filament ion source was achieved by installation of a wide ionizer filament (ribbon shape) perpendicular to the extracting slit plane between two parallel evaporators.

Isotope fractionation in aqua-gas systems: Cl(2)-HCl-Cl(-), Br(2)-HBr-Br(-) and H(2)S-S(2-).

We report calculated values of isotope fractionation factors between chlorine, bromine and sulphide hydrated anions and respective gaseous compounds: hydrogen chloride, hydrogen bromide, molecular chlorine and bromine and hydrogen sulphide. For the calculation of the reduced partition function ratios (β-factors) of hydrated Cl(-), Br(-) and S(2-) anions, we used a model of a cluster composed of the considered ion surrounded by two shells of H(2)O molecules. Only the electrostatic interaction between ion and water molecules treated as electric dipoles was taken into account.

[A role of endothelin 1 in the pathogenesis of thromboangiitis obliterans (initital news)].

Background: [corrected] Etiology and pathogenesis of thromboangiitis obliterans, an uncommon disease, but connected with high risk of leg amputation, is still unknown. Genetic predisposition and inconvenient factors of environment, especially nicotine, could initiate an immunological process, which evokes endothelial dysfunction. In histological preparation inflammation and thrombus are observed.

[New aspects of prostaglandin E1 therapeutic influence in thrombo-angiitis obliterans].

Prostaglandin E1 because of its unique protective and repaired endothelial action is used in the treatment of many diseases. The aim of the study was the investigation of prostaglandin E1 influence on some adhesive molecules profile in the patients with thrombangitis obliterans. 21 patients, aged 31-49 years (mean 40.

[Review of current etiopathogenic data of Buerger disease].

Although 75 years have passed since Buerger's disease was described as a separate nosological, its etiology and pathogenesis are not sufficiently elucidated. According to many authors the disease origin is significantly connected to genetic and environmental factors. Exposure of some patients with special genotype, mainly HLA-A9 and HLA-B5, to environmental factors, mainly nicotine, may be the base of etiology and pathogenesis of Buerger's disease.