Publications by authors named "M Cybulska"
The subjects of this research are the burial clothes of Polish King Sigismund III Vasa and his wife Constance, which were woven and embroidered with silk and metal threads. Fragments of the textiles underwent spectroscopic, spectrometric, and thermogravimetric analyses. The hydrofluoric acid extraction method was improved to isolate various classes of dyes from the textile samples that had direct contact with human remains.
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- - This study investigated the safety and effectiveness of stereotactic arrhythmia radioablation (STAR) for treating ventricular tachycardia (VT) in patients who didn't respond to traditional catheter ablation or had contraindications to it.
- - In a group of 11 patients, the trial monitored for severe adverse events, finding that only one patient experienced a significant treatment-related issue, while the others showed an 84.3% reduction in VT symptoms.
- - While STAR shows promise as a safe treatment option for certain patients, further research is needed to evaluate long-term effects and to compare it with existing treatment methods.
Article Synopsis
- BAZ1B is a protein that plays a role in various nuclear functions and is linked to tumor growth, but its specific impact on colorectal cancer (CRC) is not well-studied.
- High-density tissue microarrays were used to analyze samples from CRC patients, showing that higher BAZ1B levels correlate with larger tumor size; however, there was no connection to KRAS mutations.
- Experimental models revealed that increasing BAZ1B boosts CRC cell proliferation while reducing it through knockdown, and gene expression studies identified numerous genes affected by BAZ1B levels, indicating its significant role in CRC progression.
Proteasome machinery is a major proteostasis control system in human cells, actively compensated upon its inhibition. To understand this compensation, we compared global protein landscapes upon the proteasome inhibition with carfilzomib, in normal fibroblasts, cells of multiple myeloma, and cancers of lung, colon, and pancreas. Molecular chaperones, autophagy, and endocytosis-related proteins are the most prominent vulnerabilities in combination with carfilzomib, while targeting of the HSP70 family chaperones HSPA1A/B most specifically sensitizes cancer cells to the proteasome inhibition.
View Article and Find Full Text PDFAims: Electromechanical coupling in patients receiving cardiac resynchronization therapy (CRT) is not fully understood. Our aim was to determine the best combination of electrical and mechanical substrates associated with effective CRT.
Methods And Results: Sixty-two patients were prospectively enrolled from two centres.