Benefits and burdens of daily sacrifices and commitment in same- and different-gender couples: Explorations of proximity and direction of effects.

Research and theory document links between sacrifices and commitment in couples, yet the direction of effects remains unclear. Whereas interdependence theorists suggest that sacrifices help couples to build commitment, other scholars have suggested that being committed leads partners to sacrifice for each other. Nearly all research in this area has focused on men and women in different-gender relationships with each other.

Learning science concepts alongside language goals: A telehealth replication of a randomised controlled trial examining whether children with developmental language disorder can learn vocabulary or grammar in combination with curricular science content.

Purpose: We asked whether children with developmental language disorder can learn vocabulary or grammar targets and curricular content simultaneously. We replicated prior work integrating two language interventions into a first-grade science curriculum and extended it by testing delivery via teletherapy.

Method: A parallel arm randomised controlled trial was conducted using telehealth approaches.

Customised 96-ocular TaqMan (iCAM) microarray PCR card for rapid diagnosis of microbial keratitis.

Aim: To validate the diagnostic performance of a custom 96-micro-organism TaqMan PCR card (iCAM) for microbial keratitis (MK) from a single corneal epithelial sample.

Methods: Patients over the age of 18 referred to Cambridge University Hospital with MK were recruited in this single-site prospective cohort study between September 2021 and January 2023. An ocular-specific, customised microarray card (iCAM) was constructed according to primer and probe nucleotide sequences developed in our department to detect bacteria, viruses, and fungi commonly implicated in MK using a single corneal epithelial sample.

Photoluminescence Switching in Quantum Dots Connected with Carboxylic Acid and Thiocarboxylic Acid End-Group Diarylethene Molecules.

We contrast the switching of photoluminescence (PL) of PbS quantum dots (QDs) cross-linked with photochromic diarylethene molecules with different end groups, 4,4'-(1-cyclopentene-1,2-diyl)bis[5-methyl-2-thiophenecarboxylic acid] () and 4,4'-(1-cyclopentene-1,2-diyl)bis[5-methyl-2-thiophenethiocarboxylic acid] (). Our results show that the QDs cross-linked with the carboxylic acid end group molecules () exhibit a greater amount of switching in photoluminescence intensity compared to QDs cross-linked with the thiocarboxylic acid end group (). We also demonstrate that regardless of the molecule used, greater switching amounts are observed for smaller quantum dots.

Type I MET inhibitors cooperate with PD-1 blockade to promote rejection of hepatocellular carcinoma.

Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive conditioning; however, inhibition of MET causes upregulation of PD-ligand 1 (PD-L1) suggesting the use of these inhibitors in the context of PD-1 blockade. We sought to investigate across the Hepa1-6, HCA-1 and diethylnitrosamine (DEN) models of HCC whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with PD-1 blockade.