Publications by authors named "M Cruz-Rivera"
Transcriptome profiling of macrophages persistently infected with human respiratory syncytial virus and effect of recombinant calreticulin on immune-related genes.
Front Microbiol
September 2024
Introduction: Human respiratory syncytial virus (hRSV) is a main cause of bronchiolitis in infants and its persistence has been described in immunocompromised subjects. However, limited evidence has been reported on the gene expression triggered by the hRSV and the effect of recombinant -derived calreticulin (rTsCRT).
Methods: Using a comprehensive microarray approach, we analyzed the transcriptome profile of a macrophage cell line that has supported hRSV persistence for over 150 passages.
Article Synopsis
- * Interestingly, higher levels of certain cytokines (like IL-1, IL-6) were found in mild COVID-19 patients, along with significant cell damage in both mild and severe cases, contrasting with uninfected individuals.
- * The study highlights that mild cases show elevated levels of both pro-inflammatory and anti-inflammatory cytokines, which may link to stronger IgM and IgG antibody production, and emphasizes the need to understand the cytotoxic effects of SARS-CoV-2 on the oral mucosa.
Article Synopsis
- The study aimed to find appropriate methods for assessing the effectiveness of dextromethorphan hydrobromide (DXM) in treating cough in children aged 6-11, facing challenges like spontaneous cough resolution and lack of proper assessment tools.
- In a pilot clinical trial with 128 children, DXM showed a significant reduction in total coughs and daytime cough frequency compared to a placebo, along with self-reported improvements in cough severity.
- The findings indicated that while DXM was effective in reducing cough during the day, its impact was less clear at night due to natural decreases in cough frequency during sleep for both groups.
Intra-host genetic population diversity: Role in emergence and persistence of drug resistance among Mycobacterium tuberculosis complex minor variants.
Infect Genet Evol
July 2022
Drug resistant tuberculosis (DR-TB) is an important public health issue in different parts of the world. Mycobacterium tuberculosis complex variants (MTBC vars) preferentially infect certain hosts, limiting their distribution to different ecosystems. However, MTBC vars can infect other hosts beyond their preferred target potentially contributing to persistence of drug resistance (DR) in other niches.
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