Publications by authors named "M Crook"
Liraglutide and other glucagon-like peptide 1 receptor agonists (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. One potential mechanism is by activating neurons that inhibit the hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc). To identify these afferents, we developed a method combining rabies-based connectomics with single-nucleus transcriptomics.
View Article and Find Full Text PDFThe annual meeting for the Intermountain Branch was held in April 2024 on the campus of Brigham Young University. There were 127 branch members from Utah, Idaho, and Nevada who attended the meeting and were composed of undergraduate students, graduate or medical students, and faculty. This report highlights the diversity of, and the emerging trends in, the research conducted by American Society for Microbiology members in the Intermountain Branch.
View Article and Find Full Text PDFThe ventrolateral medulla (VLM) is a crucial region in the brain for visceral and somatic control, serving as a significant source of synaptic input to the spinal cord. Experimental studies have shown that gene expression in individual VLM neurons is predictive of their function. However, the molecular and cellular organization of the VLM has remained uncertain.
View Article and Find Full Text PDFObservation of negative surface and interface energies of quantum dots.
Proc Natl Acad Sci U S A
April 2024
Article Synopsis
- Surface energy is a key property in materials, especially nanomaterials, where a significant portion of the atoms or molecules are located at the surface.
- Traditional views hold that surface energy is positive, indicating that surface atoms are less stable than those inside due to fewer bonding interactions.
- This research reveals that in some colloidal semiconductor nanocrystals, surface energy can be negative, indicating greater stability at the surface due to strong bonds with organic ligands, and also shows favorable interfacial energy in core/shell structures, challenging previous assumptions in nanomaterial thermodynamics.
Objective: Novel lipid-lowering therapies are being introduced. Few studies exist of the real-world effectiveness of adenosine-tri-phosphate citrate lyase inhibition with bempedoic acid.
Methods: This study audited bempedoic acid therapy in 216 consecutive patients from three hospital centres - a university hospital ( = 77) and two district general hospitals ( = 106 and 33).