Publications by authors named "M Cristina Cipolla"
Article Synopsis
- Myosin-binding protein H (MyBP-H) is similar to MyBP-C and is found in skeletal muscle but has an unclear function, particularly in adult fast-twitch muscle.
- Research indicates that MyBP-H is highly expressed in prenatal rat fast-twitch muscles and larval zebrafish, hinting at its role in muscle development, which is being further investigated.
- While MyBP-H lacks key domains found in MyBP-C that modulate muscle contractility, experiments show it may function similarly by acting as a molecular "brake," raising new questions about muscle development roles.
Background: Experimental preeclampsia (ePE) has been shown to have worsened outcome from stroke. We investigated the effect of low-dose aspirin, known to prevent preeclampsia, on stroke hemodynamics and outcome, and the association between the vasoconstrictor and vasodilator cyclooxygenase products thromboxane A and prostacyclin.
Methods And Results: Middle cerebral artery occlusion was performed for 3 hours with 1 hour of reperfusion in normal pregnant rats on day 20 of gestation and compared with ePE treated with vehicle or low-dose aspirin (1.
Thrombin is a coagulation factor increased in pregnancy and further increased in preeclampsia (PE), a hypertensive disorder. Thrombin is also expressed in the brain and may have a nonhemostatic role. We characterized thrombin expression and vasoactivity in brain cerebral parenchymal arterioles (PAs) in rat models of pregnancy and PE.
View Article and Find Full Text PDFArticle Synopsis
- Preeclampsia is a pregnancy complication characterized by high blood pressure and vascular issues, influenced by the activity of oxidized low-density lipoprotein (oxLDL) and the LOX-1 receptor.
- A study used a model where female rats were given a high cholesterol diet to simulate preeclampsia, and researchers assessed the effectiveness of blocking LOX-1 to prevent changes in artery stiffness and microvascular function.
- The findings suggested that inhibiting LOX-1 may help maintain elastin levels and mitigate some structural changes in large arteries, but it did not significantly affect changes in smaller cerebral arteries or markers of oxidative stress.