Publications by authors named "M Cristina Cerquetti"
Background: The respiratory tract microbiome is essential for human health and well-being and is determined by genetic, lifestyle, and environmental factors. Patients with Common Variable Immunodeficiency (CVID) suffer from respiratory and intestinal tract infections, leading to chronic diseases and increased mortality rates. While CVID patients' gut microbiota have been analyzed, data on the respiratory microbiome ecosystem are limited.
View Article and Find Full Text PDFArticle Synopsis
- Ceftazidime-avibactam (CAZ-AVI) is an antibiotic used to treat infections caused by certain resistant bacteria, specifically carbapenemase-producing Enterobacterales, but resistance to it is increasing.
- A study analyzed CAZ-AVI-resistant Klebsiella pneumoniae (KP) from hospitalized elderly patients in Italy over a two-year period, focusing on genetic characteristics and resistance mechanisms.
- The findings revealed that all resistant isolates were multidrug-resistant, particularly concerning due to the presence of mutated KPC-3 genes and their association with high-risk bacterial clones, highlighting the need for ongoing monitoring to curb the spread of such resistant strains.
invasive disease is a severe infection that needs rapid antibiotic therapy. The aim of the study was to perform and evaluate the serotype distribution, antibiotic susceptibility and molecular characteristics of 392 invasive isolates collected during 2017-2021 in Italy. The majority of isolates were NTHi (305/392, 77.
View Article and Find Full Text PDFArticle Synopsis
- * Twelve CP-E strains from rectal swabs were analyzed through whole genome sequencing, revealing a diverse range of lineages and various resistance and virulence genes.
- * The findings show that most strains have multiple plasmids and specific genes that enhance bacterial fitness, indicating a need for strict monitoring to prevent the spread of harmful clones in healthcare environments.
Carbapenemase-producing Enterobacterales (CPE) represent a serious threat to public health worldwide. Elderly patients are at increased risk of colonisation/infection with CPE. This study aimed to evaluate the persistence of CPE colonisation and the genotypic characteristics of persistent strains in elderly people discharged from Italian hospitals.
View Article and Find Full Text PDF