Publications by authors named "M Crespin"

Article Synopsis
  • Cerebellar atrophy and hypoplasia, often detected through MRI in children with ataxia and developmental issues, are linked to leukodystrophies, which can affect brain myelin.
  • A recent study highlights two cases involving variants in the LSM7 gene: one child with a confirmed diagnosis and another with a presumed variant, suggesting LSM7's critical role in these conditions.
  • Our findings expand this understanding by presenting a new patient with similar symptoms and genetic variants in LSM7, reinforcing its association with neurodevelopmental disorders involving leukodystrophy and cerebellar atrophy.
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Increased inflammation is associated with the pathogenesis of heart failure (HF). Increased circulating levels of cytokines have been previously reported and generally associated with worse clinical outcomes. In this context, the modulation of inflammation-related parameters seems to be a reasonable therapeutic option for improving the clinical course of the disease.

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Background: Although malnutrition is frequently observed in patients with heart failure (HF), this diagnosis should be performed carefully since HF itself is associated with increased inflammatory activity, which affects body weight, functionality, and some nutritional parameters; thus, its isolated interpretation can erroneously identify surrogate markers of severity as markers of malnutrition. In this context, we aimed to evaluate the prevalence of malnutrition using different classification systems and perform a comprehensive nutritional evaluation to determine the reliability of different diagnostic techniques.

Patients And Methods: Eighty-three patients with a recent hospital admission due to HF were evaluated.

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Background: Malnutrition and sarcopenia frequently affect patients with heart failure (HF), in which clinical outcomes and survival is decreased. Thus, appropriate nutritional screening and early nutrition support are highly recommended. Currently, nutritional support is not a standard of care in patients with HF, and the use of commercially available oral supplements (OSs) could provide an additional benefit to medical treatment in these patients.

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There are limited data regarding right ventricle (RV) impairment in long-term survivors of childhood acute lymphoblastic leukemia (CLS). The aim of this study was to assess RV function in these patients using echocardiographic conventional measurements and automated RV strain. Echocardiographic recordings of 90 CLS and 58 healthy siblings from the CTOXALL cohort were analyzed.

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