Publications by authors named "M Cozma"
Acute cholangitis: a state-of-the-art review.
Ann Med Surg (Lond)
August 2024
Article Synopsis
- - Acute cholangitis is a serious bacterial infection of the bile ducts, leading to high mortality rates (up to 15%) despite advancements in treatment options like antibiotics and emergency procedures.
- - There’s been a rise in cases involving multidrug-resistant bacteria, necessitating updated antibiotic strategies based on the severity of the condition and culture results from bile samples.
- - This review focuses on the latest information regarding the epidemiology, treatment options, complications, and the importance of guiding antibiotic therapy to combat resistance, presenting a thorough approach to managing acute cholangitis.
Background: Rotavirus is a highly contagious virus responsible for a significant burden of acute gastroenteritis, particularly among infants and young children worldwide, however, vaccination against this viral agent is available. Several studies have hypothesized that rotavirus vaccination has been linked to lower rates of antibiotic resistance.
Aim: To assess the relationship between rotavirus vaccination and antibiotic resistance.
Classical Philadelphia-negative myeloproliferative neoplasms (MPNs), , polycythemia vera, essential thrombocythemia, and primary/secondary myelofibrosis, are clonal disorders of the hematopoietic stem cell in which an uncontrolled proliferation of terminally differentiated myeloid cells occurs. MPNs are characterized by mutations in driver genes, the JAK2V617F point mutation being the most commonly detected genetic alteration in these hematological malignancies. Thus, JAK inhibition has emerged as a potential therapeutic strategy in MPNs, with ruxolitinib being the first JAK inhibitor developed, approved, and prescribed in the management of these blood cancers.
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