Publications by authors named "M Cottagnoud"
Efficacy of Ceftaroline Fosamil against Escherichia coli and Klebsiella pneumoniae strains in a rabbit meningitis model.
Antimicrob Agents Chemother
December 2013
In this study, the efficacy of ceftaroline fosamil was compared with that of cefepime in an experimental rabbit meningitis model against two Gram-negative strains (Escherichia coli QK-9 and Klebsiella pneumoniae 1173687). The penetration of ceftaroline into inflamed and uninflamed meninges was also investigated. Both regimens were bactericidal, but ceftaroline fosamil was significantly superior to cefepime against K.
View Article and Find Full Text PDFCeftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against a penicillin-sensitive and a penicillin-resistant strain of S. pneumoniae in an experimental rabbit meningitis model.
View Article and Find Full Text PDFObjectives: In this study the efficacy of doripenem, a new broad-spectrum carbapenem, was tested against an Escherichia coli strain and a Klebsiella pneumoniae strain in an experimental animal model. The comparator was cefepime monotherapy.
Methods: The rabbit meningitis model was used in this study and the penetration of doripenem through uninflamed and inflamed meninges was determined.
Article Synopsis
- * In a rabbit meningitis model, ceftobiprole showed similar antibacterial activity to cefepime against specific Gram-negative pathogens, with notable superiority against a resistant H. influenzae strain.
- * The drug's ability to penetrate the cerebrospinal fluid during inflammation was found to be about 16% of serum levels, significantly higher than the 2% penetration observed with uninflamed meninges.