[The effect of chemical noxae on the health status of a group of workers in the chemical industry of Săvineşti].

The paper presents the study on the effect of the industrial xenobiotics against some biochemical indicators, in view to detect, precociously, the probable significant changes. There are presented the medium, minimum, maximum and median value for the following parameters: total proteins, haemoglobin and glucose for 112 workers exposed or not exposed to specific noxae--benzen, phenol, cyclohexanone. The analysis of the results shows decreased values for some workers, even at the inferior limit, in rapport with the normal values, for the parameters studied.

[Evolution of the first hospital pharmacy in Saint-Spiridon hospital of Iasi].

The first Saint-Spiridon hospital was built in 1757. A pharmacy, managed by Andonie Feierman, was opened in 1765. After his death, foreign pharmacists succeeded one another until 1827, when was mentioned the first rumanian pharmacist, Ioan Padure.

[Peroxide radicals in the metabolism of toxic substances].

The free radicals resulting from the metabolism of oxygen and some xenobiotics, can induce, when a limit concentration is exceeded, toxic effects due to their action on DNA, enzymes and fatty acids. Therefore, the association of oxygen therapy with drug administration may have a more or less beneficial effect. Thus, in a long-term treatment with drugs which by metabolized release free radicals, the use of exogenous compounds for protecting the human body need to be administered.