Publications by authors named "M Coppi"
Article Synopsis
- Multi-drug resistant (MDR) bacteria, particularly carbapenem-resistant Klebsiella pneumoniae (CR-Kp), pose significant health risks due to their strong resistance to antibiotics and prevalence in hospitals.
- *The study isolated four lytic bacteriophages from sewage, specifically targeting high-risk CR-Kp clones (ST307 and ST147), showing that they can effectively kill these harmful bacteria.
- *These phages demonstrated stability across various conditions and lacked antibiotic resistance genes, making them potential candidates for alternative infection treatments and further research.*
Alzheimer's disease (AD) is a neurodegenerative process responsible for almost 70% of all cases of dementia. The clinical signs consist in progressive and irreversible loss of memory, cognitive, and behavioral functions. The main histopathological hallmark is the accumulation of amyloid-ß (Aß) peptide fibrils in the brain.
View Article and Find Full Text PDFAntimicrobial susceptibility testing (AST) from blood culture (BC) may take several days, limiting the eventual impact on antimicrobial stewardship. Hence, rapid AST systems represent a valuable support in shorting the time-to-response. In this work, the Quantamatrix dRAST system (dRAST) was evaluated for rapid AST on 100 monomicrobial BCs (50 Gram-negatives and 50 Gram-positives), including several isolates with clinically relevant resistance mechanisms.
View Article and Find Full Text PDFFIM-1 metallo-β-lactamase was previously detected in sporadic clinical isolates. Here, we report on FIM-1-positive from two patients who had shared the same ward in a long-term acute care rehabilitation hospital. Whole-genome sequencing analysis revealed close relatedness of these isolates, which belonged to an ST235 sublineage (clade 8/14) different from those previously reported.
View Article and Find Full Text PDFObjectives: We performed a multicentre study (2020-2022) to compare the activity of ozenoxacin and comparator agents against and clinical isolates from skin and soft-tissue infections (SSTI).
Methods: A total of 1725 isolates (1454 and 271 ) were collected in 10 centres from eight countries between January 2020 and December 2022. Antimicrobial susceptibility testing was determined (microdilution-SENSITITRE).