Genome assembly of the southern pine beetle ( Zimmerman) reveals the origins of gene content reduction in .

also known as southern pine beetle (SPB), is the most damaging insect forest pest in the southeastern United States. Genomic data are important to provide information on pest biology and to identify molecular targets to develop improved pest management approaches. Here, we produced a chromosome-level genome assembly of SPB using long-read sequencing data.

Childhood maltreatment associated with adolescent peer networks: Withdrawal, avoidance, and fragmentation.

Background: Childhood maltreatment can affect subsequent social relationships, including different facets of peer relationships. Yet, how prior maltreatment shapes adolescents' connections within school peer networks is unclear, despite the rich literature showing the importance of this structural aspect of social integration in adolescence.

Objectives: This study examines how childhood physical abuse, emotional abuse, sexual abuse, and physical neglect predict adolescent social network structure as withdrawal, avoidance, and fragmentation among peers.

CAPRI-Q: The CAPRI resource evaluating the quality of predicted structures of protein complexes.

Protein interactions are essential for cellular processes. In recent years there has been significant progress in computational prediction of 3D structures of individual protein chains, with the best-performing algorithms reaching sub-Ångström accuracy. These techniques are now finding their way into the prediction of protein interactions, adding to the existing modeling approaches.

Diagnosis, prevention and risk-management of drug-induced liver injury due to medications used to treat mycobacterium tuberculosis.

Introduction: Many of the first line medications for the treatment of active and latent M. tuberculosis are hepatoxic and cause a spectrum of anti-tuberculosis drug induced liver injury (ATLI), including acute liver failure (ALF). Despite advances in recognition of and prevention of ATLI, isoniazid remains one of the leading causes of DILI as well as drug-induced ALF.

Hepatocyte-specific Epidermal Growth Factor Receptor Deletion Promotes Fibrosis but has no Effect on Steatosis in Fast-food Diet Model of Metabolic Dysfunction-associated Steatotic Liver Disease.

Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB inhibitor, Canertinib, in reducing steatosis and fibrosis in a murine fast-food diet (FFD) model of MASLD. The current study explores the effects of hepatocyte-specific ErbB1 (ie, epidermal growth factor receptor [EGFR]) deletion in the FFD model.