Publications by authors named "M Convento"
Chitosan is one of the most abundant biopolymers on earth. It is used as a nontoxic alternative in a wide range of medicines, packaging, adhesives, and flame retardants. Chitosan is poorly soluble in neutral or alkaline solutions, but it dissolves in solutions of weak acids, such as acetic acid or citric acid, both of which occur naturally.
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- - UC-EVs (umbilical cord mesenchymal stem cell-derived extracellular vesicles) are promising natural nanocarriers that can deliver miRNA-126, which helps maintain blood vessel health and protects kidneys from injury.
- - The study tested the effectiveness of UC-EVs carrying miRNA-126 and anti-miRNA-126 on kidney cells exposed to damage from gentamicin, showing improved cell cycle regulation and reduced DNA damage.
- - Results suggest that UC-EVs not only transport beneficial miRNA but may also contain other protective components that enhance their nephroprotective effects in kidney injury scenarios.
Unlabelled: Containing information molecules from their parent cells and inclining to fuse with targeted cells, bone marrow mesenchymal stromal cells-derived extracellular vesicles (MSCs- EV) are valuable in nanomedicine.
Background: The effects of aging on the paracrine mechanism and in the production and action of MSCs-EV and their cargos of miR-26a and siRNA-26a for the treatment of tubular renal cells under nephrotoxicity injury remain unelucidated.
Objective: The purpose of this study was to evaluate MSCs-EV of different ages and their ability to deliver the cargos of miR-26a and siRNA-26a to target renal tubular cells affected by nephrotoxicity injury.
Introduction: Glyphosate is the most widely used herbicide worldwide and in Brazil. There is currently increasing concern about the effects of glyphosate on human health. The Brazilian Institute for Consumer Protection showed data on the presence of glyphosate in some of Brazil's most consumed ultra-processed products.
View Article and Find Full Text PDFMesenchymal stromal cells (MSCs) obtained from bone marrow are a promising tool for regenerative medicine, including kidney diseases. A step forward in MSCs studies is cellular conditioning through specific minerals and vitamins. The Omega-3 fatty acids (ω3) are essential in regulating MSCs self-renewal, cell cycle, and survival.
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