Publications by authors named "M Constantinescu"

: The aim is to bring attention to the existence of a rare type of trauma of the hand, high-pressure injection injury, that appears to be minor with negligible signs and symptoms within the first hours after the accident, but in reality, produces significant tissue destruction with severe consequences. Recognizing this type of trauma by medical personnel, understanding the mechanisms involved, and knowing the etiological and prognostic factors can lead to early treatment initiation and avoid severe mutilating sequelae. : A retrospective study on 16 patients diagnosed with high-pressure injection injuries, including water, air, paint, paint mixed paint with thinner, petroleum jelly, and lime (washable paint containing calcium oxide).

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  • Ischemia/reperfusion injury (IRI) occurs when blood flow is restored after a period of interrupted supply, leading to inflammatory responses and neutrophil recruitment that release NETs (neutrophil extracellular traps).
  • In a study on pig forelimbs, researchers examined the effects of different durations of ischemia (1 hour vs. 9 hours) and monitored various indicators of tissue damage and NET formation.
  • Findings indicated that longer ischemia worsens damage, with a significant increase in NETs and citrullinated fibrinogen levels in the 9-hour ischemia group compared to the 1-hour group, highlighting the detrimental role of NETs in IRI.
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  • This study explores the immune rejection of cartilage in vascularized composite allotransplantation (VCA), which is vital for restoring motor function in joint transplants.
  • Using a swine model, researchers analyzed tissue samples from grafts that experienced severe skin rejection and found evidence of immune attacks on cartilage but with less severity than skin and muscle.
  • The findings indicate that cartilage is not immune from rejection in VCA, showing significant immune response activity, including markers of cell death, although it endures milder inflammation compared to other tissues.
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The surgical-oncological treatment of pelvic and perineal malignancies is associated with a high complication rate and morbidity for patients. Modern multimodal treatment modalities, such as neoadjuvant radio-chemotherapy for anal or rectal cancer, increase the long-term survival rate while reducing the risk of local recurrence. Simultaneously, the increasing surgical radicality and higher oncological safety with wide resection margins is inevitably associated with larger and, due to radiation, more complex tissue defects in the perineal and sacral parts of the pelvic floor.

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