Publications by authors named "M Concepcion Lozada"
A key challenge of the modern genomics era is developing empirical data-driven representations of gene function. Here we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-wide genotype-phenotype maps comprising CRISPR-Cas9-based knockouts of >20,000 genes in >30 million cells. Our optical pooled cell profiling platform (PERISCOPE) combines a destainable high-dimensional phenotyping panel (based on Cell Painting) with optical sequencing of molecular barcodes and a scalable open-source analysis pipeline to facilitate massively parallel screening of pooled perturbation libraries.
View Article and Find Full Text PDFObjective: Our study aimed to identify and describe pulmonary complications and its associated risk factors in children with suspected or confirmed obstructive sleep apnea (OSA) who underwent tonsillectomy or adenotonsillectomy in a tertiary government hospital.
Methods: We conducted a retrospective cohort study. Medical charts of pediatric patients with suspected or confirmed OSA who were admitted for tonsillectomy or adenotonsillectomy from January 1, 2016 to December 31, 2020 were retrieved and reviewed.
Objective: Our study aimed to determine the clinical profile and pulmonary function of pediatric patients with Duchenne Muscular Dystrophy (DMD). We also characterized the stages of progression of the disease and determined their potential association with spirometry variables.
Methods: In this cross-sectional study, we used data obtained from a review of medical records of all pediatric patients (0-18 years old) with DMD seen in a multidisciplinary neuromuscular clinic of a tertiary government hospital from August 2018 until March 2020.
Article Synopsis
- The study evaluates the mechanical and physical properties of 21 different dental dam sheets used for isolation, measuring parameters like thickness, rupture force, elongation, and ultimate tensile strength, alongside their costs.
- Testing involved cutting samples and using a universal testing machine to assess properties while also examining the sheets' structure and composition through various methods including scanning electron microscopy.
- Results showed variations in thickness and mechanical performance, with Flexidam being the thickest and the non-latex Sanctuary dam exhibiting the highest elongation, while the Bassi dental dam had the best ultimate tensile strength.
Adaptation and Biomechanical Performance of Custom-Fit Mouthguards Produced Using Conventional and Digital Workflows: A Comparative In Vitro Strain Analysis.
Dent Traumatol
February 2025
Article Synopsis
- The study compared custom-fit mouthguards made from conventional plaster versus 3D printed models, focusing on their thickness, fit, and shock-absorption qualities.
- The 3D printed mouthguards demonstrated better adaptation to tooth surfaces, although both types maintained similar thickness and effectively reduced impact strain.
- Results indicate that both types of mouthguards meet performance standards, with voids having no significant effect on their functionality.