Publications by authors named "M Compagnone"
In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. Currently, the manufacturing process to produce clinical-grade CAR-T cells is complex, time-consuming, and highly expensive.
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- A case of ventricular thrombosis linked to myocarditis from immune checkpoint inhibitors (ICIs) presented as a myocardial infarction and worsened by severe cardiogenic shock.
- The rare occurrence of intraventricular thrombus formation in ICI-related myocarditis complicates diagnosis, particularly when distinguishing it from tumor masses in cancer patients.
- Effective diagnosis requires thorough clinical assessment and advanced imaging techniques, as cardiovascular complications from ICIs, though infrequent, can have high mortality rates.
Article Synopsis
- Varicocele affects up to 15% of men and is linked to infertility; various surgical and radiological methods exist for treatment, but their effectiveness is uncertain.
- A study comparing the Ivanissevich surgical technique and sclerotherapy in 94 patients found that sclerotherapy significantly improved sperm concentration, while surgical treatment reduced the number of patients with oligozoospermia.
- Overall, the study did not determine a clear advantage of one method over the other but highlighted the importance of considering sperm bio-functional parameters in future research.
Background: Intramyocardial dissecting haematoma (IDH) is a rare life-threatening event usually complicating an acute myocardial infarction. Poor data exist about diagnosis, management, and outcome.
Case Summary: We reported a case of giant IDH managed conservatively, thanks to stable clinical status and haemodynamics, which evolved towards resorption.
Background: There is little data on the outcome of balloon aortic valvuloplasty (BAV) in relation to valve dimensions and calcification patterns. The procedure is not standardized, particularly the choice of balloon size.
Methods: This retrospective multicenter study focused on BAV efficacy and safety by analyzing the relationship between balloon size, annulus geometry (i.