Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54.

Context: Loss of function of the G protein-coupled receptor of kisspeptins (GPR54) was recently described as a new cause of isolated hypogonadotropic hypogonadism. In vivo studies performed in several species have confirmed the major role of kisspeptins in neuroendocrine regulation of the gonadotropic axis and therefore sexual maturation.

Objective: The objective of this study was to specify the exact contribution of kisspeptins and GPR54 to the initiation of puberty in humans.

[Clinical assessment of toxics deleterious to fertility].

This paper reviews the main toxics which are deleterious to fertility. Toxics are identified through in vitro, animal and clinical studies. The practitioner tries to assess whether a couple consulting for infertility has been exposed to such toxics.

[Human life, the fruit of a meeting -- in connection with couple infertility].

Reproductive Medicine is first seen in the light of Michel Foucault's work, The Birth of the Clinic. Archaeology of the Medical Perception. Then, the different levels of the procreative meeting are described: emotional, sexual and cultural meetings.

[Role of intrauterine insemination as treatment for specific factor of fertility].

The role of intrauterine insemination as treatment for specific factor of infertility and for empiric treatment in idiopathic infertility is hereby described. A review of the different prerequisite evaluations is presented: ovarian age, pelvis evaluation and implantation parameters and negative lifestyle (woman weight and toxics). The efficiency of the treatment as evaluated by different studies is described in terms of pregnancy rate and obstetrical and perinatal outcome.