Publications by authors named "M Coemans"
Article Synopsis
- The study investigates how competing risks, like allograft failure and death with a functioning graft, affect the performance of prognostic models used for kidney transplant recipients.
- The research involves 11,046 kidney transplant recipients across 10 countries, developing models using various regression techniques to predict long-term graft failure while carefully evaluating their accuracy and reliability.
- Results indicate that both standard Cox models and competing risk models provide similar predictions for graft failure, with high concordance indices, confirming their usefulness in clinical settings.
Graft failure and recipient death with functioning graft are important competing outcomes after kidney transplantation. Risk prediction models typically censor for the competing outcome thereby overestimating the cumulative incidence. The magnitude of this overestimation is not well described in real-world transplant data.
View Article and Find Full Text PDFThe Banff 2022 consensus introduced probable antibody-mediated rejection (AMR), characterized by mild AMR histologic features and human leukocyte antigen (HLA) donor-specific antibody (DSA) positivity. In a single-center observational cohort study of 1891 kidney transplant recipients transplanted between 2004 and 2021, 566 kidney biopsies were performed in 178 individual HLA-DSA-positive transplants. Evaluated at time of the first HLA-DSA-positive biopsy of each transplant (N = 178), 84 of the 178 (47.
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