Matrix metalloproteinase-9 expression in the nuclear compartment of neurons and glial cells in aging and stroke.

Matrix metalloproteinases (MMPs) are well-recognized denominators for extracellular matrix remodeling in the pathology of both ischemic and hemorrhagic strokes. Recent data on non-nervous system tissue showed intracellular and even intranuclear localizations for different MMPs, and together with this, a plethora of new functions have been proposed for these intracellular active enzymes, but are mostly related to apoptosis induction and malign transformation. In neurons and glial cells, on human tissue, animal models and cell cultures, different active MMPs have been also proven to be located in the intra-cytoplasmic or intra-nuclear compartments, with no clear-cut function.

Massive cortico-subcortical ischemic stroke with a consecutive hemorrhagic event: a case report.

Background: We report a case of a 78-year-old woman with a large cerebral infarction probably due to athermanous embolism following atrial fibrillation.

Case Description: The patient, known with atrial fibrillation, high blood pressure and heart failure, complained of headache and motor impairment on the left side of the body. CT imaging revealed a subacute ischemic lesion in the right fronto-occipital lobes, and an old ischemic lesion in the right fronto-parietal lobes.

Fractal analysis of astrocytes in stroke and dementia.

The varied morphological forms in which astrocytes occur in brain of ischemic/hemorrhagic stroke and Alzheimer's disease (AD) patients are complex and the mechanisms that drive their formation are not yet properly understood. Subjective differences can be described between these pathologies in what it concerns astrocyte implication, but these have not been yet subjected to a morphometrical quantification. Here we apply a fractal dimension (FD) analysis algorithm to differentiate both between fibrous, protoplasmatic and activated astroglia; but also between the three pathological conditions studied.

An unusual metastasis of a papillary thyroidian carcinoma with follicular pattern.

The case of a 67-year-old man is presented. He was admitted for the presence of a left parietal tumour with progressive growing, without any other objective or subjective symptomatology. CT-scan detects a left parietal osteolytic area.

Diagnosis problems in a case of carcinoma with clear cells at the uterine cervix level.

We present the case of a patient of 50 years old who developed a tumoral formation at the level of the uterine cervix. The histopathologic examination beside the clinic examination constituted an important element in diagnosis elaboration. The histopathologic study performed on serial sections from the tumoral fragment of the cervix allowed establishment of the positive diagnosis through the exclusion of some lesions with microscopic relatively similar images but which have a complete different prognosis and therapy.