Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy.

Colorectal cancer (CRC) remains one of the most prevalent and lethal cancers worldwide, prompting ongoing research into innovative therapeutic strategies. This review aims to systematically evaluate the role of gelatinases, specifically MMP-2 and MMP-9, as therapeutic targets in CRC, providing a critical analysis of their potential to improve patient outcomes. Gelatinases, specifically MMP-2 and MMP-9, play critical roles in the processes of tumor growth, invasion, and metastasis.

DNA barcoding of invasive Gambusia holbrooki Girard, 1859 and Atherina boyeri Risso, 1810 inhabiting Upper Euphrates River Basin, Türkiye.

The main contributor to Türkiye's abundant freshwater fish biodiversity is its geographic location. This fauna consists of endemic, native, and non-native fish species. The introduction of Gambusia holbrooki Girard, 1859 to Lake Amik in the 1920s for the biological control of malaria was the first introduction of nonnative species to Türkiye.

Enhanced luminescence and quenching mechanisms in Na⁺ Co-doped K₇CaY₂(B₅O₁₀)₃:Tb phosphors under UV radiation.

This study investigates the structural and luminescent properties UV radiation of Tb³⁺-doped K₇CaY₂(B₅O₁₀)₃ (KCYBO) phosphors prepared using a microwave-assisted sol-gel method, with a focus on the impact of Na⁺ co-doping. Tb³⁺ ions were effectively integrated as evidenced by X-ray diffraction (XRD) and Rietveld analysis, without disrupting the crystal structure. Photoluminescence (PL) analysis showed intense green emissions at 542 nm, which are due to the D₄ → F₅ transition in Tb³⁺.

Determination of Bone Fracture Risk in Kidney Transplant Recipients With FRAX Score.

Background: It is thought that the Fracture Risk Assessment Tool (FRAX) score of the World Health Organization (WHO) determines a 10-year fracture risk. This study aimed to investigate the major osteoporotic fracture (MOF) and hip fracture (HF) values determined with the FRAX score and practicality of the FRAX score in kidney transplant recipients (KTRs).

Methods: This study was conducted with 44 female and 59 male KTRs and 100 subjects in the healthy control group.

Relationship of Dickkopf-1 With Atherosclerosis and Arterial Stiffness in Renal Transplant Recipients.

Introduction: Dickkopf wingless (Wnt) signaling pathway inhibitor-1 (DKK-1) is a potent antagonist of the WNT canonical signaling pathway. DKK-1 is a substance that exerts anabolic effects on bone and is also involved in vascular cell regulation. The study aimed to determine the relationship of DKK-1 with atherosclerosis as determined by carotid artery intima-media thickness (CA-IMT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (baPWV) in renal transplant recipients (RTRs).