Publications by authors named "M Coathup"

Cerium oxide based nanozymes are intensively studied due to their catalytic activity and structural flexibility. Such nanozymes have a great future potential in human therapeutics and antimicrobial activity. The structural complexity of their surfaces enables a great variety of enzyme mimetic activities.

View Article and Find Full Text PDF

As both the proportion of older people and the length of life increases globally, a rise in age-related degenerative diseases, disability, and prolonged dependency is projected. However, more sophisticated biomedical materials, as well as an improved understanding of human disease, is forecast to revolutionize the diagnosis and treatment of conditions ranging from osteoarthritis to Alzheimer's disease as well as impact disease prevention. Another, albeit quieter, revolution is also taking place within society: human augmentation.

View Article and Find Full Text PDF

The repair of large bone defects due to trauma, disease, and infection can be exceptionally challenging in the elderly. Despite best clinical practice, bone regeneration within contemporary, surgically implanted synthetic scaffolds is often problematic, inconsistent, and insufficient where additional osteobiological support is required to restore bone. Emergent smart multifunctional biomaterials may drive important and dynamic cellular crosstalk that directly targets, signals, stimulates, and promotes an innate bone repair response following age-related biological decline and when in the presence of disease or infection.

View Article and Find Full Text PDF

Hemorrhage is one of the leading causes of preventable death. While minor injuries can be treated mainly by conventional methods, deep and irregular wounds with profuse bleeding present significant challenges, some of which can be life-threatening and fatal. This underscores the need to develop easily applicable FDA-approved hemostatic treatments that can effectively stanch blood loss at the point of care before professional medical care.

View Article and Find Full Text PDF
Article Synopsis
  • Community-associated and hospital-acquired bacterial infections pose significant global health challenges, exacerbated by ineffective standard disinfection methods on high-touch surfaces.
  • Researchers developed a ceria-silver nanozyme that effectively eliminates harmful bacteria like Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus on both wet and dry surfaces by damaging their cellular structures.
  • Mechanisms of action include the production of reactive oxygen species (like hydrogen peroxide) and electrostatic interactions, leading to bacterial respiration loss and eventual cell death, while showing lasting antibacterial effects in a real clinical setting.
View Article and Find Full Text PDF