Publications by authors named "M Clemente"
Combined left atrial appendage occlusion and catheter ablation for atrial fibrillation versus isolated left atrial appendage occlusion: A systematic review and meta-analysis.
Mariana R C Clemente Denilsa D P Navalha Vinicius Bittar Thomaz Alexandre Costa Gabriel Prusch Fernandes
Int J Cardiol
October 2024
Background: Data on the effects of combined left atrial appendage occlusion (LAAO) and catheter ablation (CA) for atrial fibrillation (AF) remain limited. We aimed to perform a systematic review and meta-analysis comparing LAAO and CA versus isolated LAAO.
Methods: We systematically searched PubMed, Embase, and Cochrane Library for studies comparing combined LAAO and CA versus isolated LAAO in patients with atrial fibrillation.
Article Synopsis
- The study investigates the characteristics and quality of life (QoL) of patients diagnosed with childhood-onset craniopharyngioma, analyzing data from 66 patients treated between 2008 and 2022.
- Most patients were diagnosed at a young age (around 5 years) and faced long-term complications, including significant endocrine issues and visual deficits.
- QoL scores indicated that while patients rated their QoL higher than their parents did, factors like repeated surgeries, hypothalamic involvement, and the use of radiotherapy were found to negatively impact overall QoL.
Article Synopsis
- Genetic defects in the TSH receptor can lead to various thyroid issues, such as thyroid dysgenesis or dyshormonogenesis, resulting in a wide range of symptoms from severe congenital hypothyroidism to mild hormonal imbalances.
- A study analyzed 160 pediatric patients with thyroid dyshormonogenesis using high-throughput gene panels and in vitro tests to assess the impact of recognized genetic variants on thyroid function.
- The findings showed that out of the patients studied, 3.13% had significant genetic variants affecting their thyroid health, with different variants exhibiting varying levels of functional impact, underscoring the necessity of genetic testing for accurate diagnosis.