Publications by authors named "M Claydon"
Background: There is a paucity of data examining anterior lumbar interbody fusion (ALIF) with pedicle-screw fixation (ALIF-PSF) or without (standalone, sa-ALIF) for the treatment of low-grade isthmic spondylolisthesis (IS). Treating pathology with sa-ALIF reduces costs, operative times, and posterior access morbidity. This study aimed to investigate the clinical and radiographic outcomes of sa-ALIF for the management of low-grade IS compared with an ALIF-PSF cohort.
View Article and Find Full Text PDFPsychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid-acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood. For example, key questions such as whether antidepressant and psychedelic effects involve related or independent mechanisms are unresolved.
View Article and Find Full Text PDFArticle Synopsis
- The research analyzes data from 605 patients and establishes a correlation between TIAO rates and surgical procedures, indicating that single or multilevel total disc replacements (TDR) have higher TIAO rates compared to anterior lumbar interbody fusions (ALIF).
- Key findings reveal that the risk for TIAO is significantly elevated at the L4/5 level, with rates reaching as high as 65.2%, although no patients experienced serious postoperative complications related to thrombosis.