Septoria tritici blotch (STB), caused by the Dothideomycete fungus Zymoseptoria tritici, is one of the most damaging diseases of bread wheat (Triticum aestivum) and the target of costly fungicide applications. In line with the fungus's apoplastic lifestyle, STB resistance genes isolated to date encode receptor-like kinases (RLKs) including a wall-associated kinase (Stb6) and a cysteine-rich kinase (Stb16q). Here we used genome-wide association studies on a diverse panel of 300 whole-genome shotgun-sequenced wheat landraces (WatSeq consortium) to identify a 99-kb region containing six candidates for the Stb15 resistance gene.
View Article and Find Full Text PDFStudy DesignNarrative Review.ObjectivesTo summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study.MethodsA narrative review of all published manuscripts from the EPOSO study was undertaken.
View Article and Find Full Text PDFBackground: High-grade gliomas (HGG) occur in any central nervous system (CNS) location and any age. HGGs in teenagers/young adults (TYA) are understudied. This project aimed to characterise these tumours to support accurate patient stratification.
View Article and Find Full Text PDFRecently there have been calls in health psychology to re-examine the assumption that goals must be specific to be most effective, and to understand when and why nonspecific goals may produce comparable effects to specific goals. In particular, open goals have received increasing attention from both research and applied perspectives. However, there has not yet been a clear and robust definition of open goals, without which there is a risk of inaccurate or inconsistent research and implementation.
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