Environmental and evolutionary controls in animal-sediment interactions at the onset of the Cambrian explosion.

The Cambrian explosion was a time of groundbreaking ecological shifts related to the establishment of the Phanerozoic biosphere. Trace fossils, which are the products of animals interacting with their substrates, provide a key record of the diversification of the benthos and the evolution of behavioral complexity through this interval. The Chapel Island Formation of Newfoundland in Canada hosts the most extensive trace-fossil record from the latest Ediacaran to Cambrian Age 2, spanning about 20 million years continuously.

AChR-blocking antibodies and complement system dynamics: evaluating their interplay and clinical implications in myasthenia gravis.

Background: Myasthenia gravis (MG) is an autoimmune disorder characterised by autoantibodies (abs) targeting proteins at the neuromuscular junction, primarily the acetylcholine receptor (AChR). While the role of AChR-binding abs is well-established, the pathogenicity and clinical relevance of AChR-blocking antibodies in MG, and their association with complement system, remain less understood.

Aims: This study aims to provide comprehensive insights into the prevalence and interplay of AChR-blocking antibodies and the complement system in an Argentinian MG cohort, investigating their relationships with disease activity.

How did previously obese children and adolescents behave during the SARS-CoV-2 pandemic in relation to weight gain?

Objective: The objective of this study was to analyze the implications of social contingency measures and interruption of outpatient follow-up on weight gain in children and adolescents with a previous diagnosis of obesity.

Methods: This is an observational study with data from electronic medical records of children and adolescents followed up at a specialized outpatient clinic from 2019 to 2023. Weight gain, height, BMI variation, BMI z-score, laboratory tests, and associated comorbidities were analyzed.

Integrated surveillance for Oropouche Virus: Molecular evidence of potential urban vectors during an outbreak in the Brazilian Amazon.

The Oropouche Virus (OROV) has Culicoides paraensis as its main vector in the urban cycle. Diagnoses of acute febrile cases and entomological collections were performed between January and April 2024 in the urban setting of Porto Velho, a city located in the western Brazilian Amazon. A total of 904 human samples were evaluated using RT-qPCR, of which 328 were positive for OROV.