Endogenic non-enzymatic antioxidative system of polyester grafts during their healing.

Objective: Non-enzymatic low-molecular antioxidants are one of the important mechanisms which protect cells against the toxic effect of oxygen. The aim of the present study was to determine the content of glutathione, glutathione reductase, and ascorbic acid in the principal layers of polyester grafts. INTERVENTIONS AND MEASURES: The experiments were carried out on 24 mongrel dogs, in which polyester double velour DALLON grafts were implanted.

Activity and distribution of superoxide dismutase in the layers of polyester grafts.

The aim of the present study was to evaluate superoxide dismutase (Cu, Zn-SOD) activity in the principal layers of polyester grafts implanted into the abdominal aorta of dogs. The grafts were examined 7 days and 1, 4 and 12 months after the operation. It was found that SOD activity occurred in all polyester graft layers during the whole experiment.

Ethanol ingestion decreases superoxide dismutase activity and diminishes -SH compounds in the liver and red blood cells in rats.

SOD activity and -SH compounds in the liver and RBCs, and some hematological parameters were investigated in control rats and in those submitted to chronic (3 months) intoxication with ethanol. We found significantly lower SOD activity and a decrease in -SH groups in the liver and RBCs of ethanol-treated rats in comparison with the control group. The hemoglobin content and mean corpuscular hemoglobin concentration were reduced, while mean corpuscular volume of RBCs was increased when compared with the control group.

The role of free oxygen radicals in children with chronic viral hepatitis B.

Lipid peroxidation of polyunsaturated fatty acids, being important components of cellular membranes, caused by free oxygen radicals is considered to be one of the main causes of hepatocyte injury. The aim of this study is to estimate the malondialdehyde (MDA) level in the red blood cells of children with chronic viral hepatitis B. The decrease of MDA concentration along with the clinical and serological improvement in children with chronic hepatitis B was observed.

The 21-aminosteroid U-74389G protects the antioxidant enzymes in the ischemia/reperfusion-induced rat brain damage.

The antioxidant enzymatic system in the ischemia/reperfusion induced brain injury in rats after U-74389G administration was evaluated. Ischemia/reperfusion caused a decrease in the activities of superoxide dismutase and glutathione reductase, as well as of total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of U-74389G lead to restoring to normal values of all above parameters.