Publications by authors named "M Christine Thurnheer"
Article Synopsis
- A study was conducted to compare the effectiveness of 24-hour perioperative antibiotic prophylaxis (PAP) versus extended-duration PAP in preventing surgical site infections (SSIs) following cystectomy with urinary diversion, as existing guidelines recommend 24 hours or less but often extended durations are used in practice.!* -
- The randomized clinical trial included 193 patients and aimed to establish whether 24-hour PAP is noninferior to extended PAP in terms of SSI rates within 90 days post-surgery, with findings showing no significant difference in SSI occurrences between the two groups.!* -
- The results indicated that 8.4% of patients on 24-hour PAP experienced SSIs compared to 12.2% in the extended
An uncommon occurrence in which Graves disease (GD) coincides with autonomous functioning thyroid nodules (AFTNs) is termed Marine-Lehnhart syndrome (MLS). While hyperfunctioning nodules in MLS are commonly benign, there exists a rare potential for malignancy. A 41-year-old male patient was initially managed conservatively upon being diagnosed with MLS type 1.
View Article and Find Full Text PDFIntroduction: Exploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection.
Methods: Participants treated for recent HCV in an international trial (enrolled 2017-2019) were followed at 3-monthly intervals for up to 2 years to assess longitudinal behaviours.
Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years.
Lancet Healthy Longev
May 2023
Background: Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated HIV infection and during suppressive ART.
Methods: In this longitudinal study, conducted over 17 years in HIV outpatient clinics in Switzerland, we applied 5 established epigenetic age estimators (epigenetic clocks) in peripheral blood mononuclear cells (PBMCs) in Swiss HIV Cohort Study participants before or during suppressive ART.
Background: People with human immunodeficiency virus (HIV; PWH) have increased cardiovascular risk. Higher leukocyte count has been associated with coronary artery disease (CAD) events in the general population. It is unknown whether the leukocyte-CAD association also applies to PWH.
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