Publications by authors named "M Christ-Crain"
Background: Use of serum procalcitonin (PCT), an inflammatory biomarker for bacterial infections, has shown promising results for early stopping antibiotic treatment among patients with respiratory infections and sepsis. There is need for additional data regarding effectiveness and safety of this concept among patients with cancer.
Methods: Individual data of patients with a documented diagnosis of cancer and proven or suspected respiratory infection and/or sepsis were extracted from previous trials where adult patients were randomized to receive antibiotic treatment based on a PCT protocol or usual care (control group).
The European Society of Endocrinology (ESE) and the Union Européenne des Médecins Spécialistes (U.E.M.
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- MDMA (ecstasy) is being studied as a treatment for PTSD but has the risk of causing low sodium levels (hyponatremia) after just one dose due to factors like vasopressin release and excessive drinking.
- This study aimed to analyze how often and severely hyponatremia occurs after a single MDMA dose, looking at underlying hormonal mechanisms and whether limiting fluid intake could reduce this risk.
- Out of 96 participants, about 31% experienced hyponatremia, but none in the group with fluid restrictions, suggesting that managing fluid intake could lessen the chance of developing this complication.
The use and misuse of opioids are a growing global problem. Although the effects of these drugs on the human endocrine system have been studied for decades, attention on their related clinical consequences, particularly on the hypothalamic-pituitary system and bone health, has intensified over recent years. This Statement appraises research data related to the impact of opioids on the gonadal and adrenal function.
View Article and Find Full Text PDFObjective: Differentiating between arginine vasopressin deficiency (AVP-D) and primary polydipsia (PP) requires a copeptin stimulation test. We aimed to characterize changes in apelin, an endogenous hormone antagonizing AVP, upon copeptin stimulation tests.
Design: Post hoc secondary analysis of a multi-centric cross-over diagnostic study (NCT03572166).